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Postfix IPv4 Only
I have a postfix SMTP relay buried deep in a network behind proxy servers, all the infrastructure [sadly] is IPv4 only. This works, yet one ends up with many log messages like:
connect to smtp.office365.com[2603:1036:304:2857::2]:587: Network is unreachable
The server attempts if IPv6 result from the DNS lookup first. So let's make postfix use IPv4 only.
postconf -e inet_protocols=ipv4
That's it! No more "unreachable" log messages.
BTW, the default value of inet_protocols is "all". Set it back to that value to re-enable IPv6.